Trials / Active Not Recruiting
Active Not RecruitingNCT03336658
Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer
Assessment of Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer Patients: a Prospective Observational Study
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 150 (estimated)
- Sponsor
- Insel Gruppe AG, University Hospital Bern · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- —
Summary
All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds. then, the intratumoral buds (ITB) in the densest Region of Tumor buds, namely the "hot spot" will be counted. Subsequently, the probability of N stage (lymphnodes), M stage (metastases) and disease free survival (DFS) will be calculated based on an existing logistic Regression model already developed by our previous retrospective work. Additionally, a Standardisation of ITB using a well- established Software will develop an algorithm which will help to eliminate inter- observer variability of Tumor budding Counts.
Conditions
Timeline
- Start date
- 2015-10-01
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
- First posted
- 2017-11-08
- Last updated
- 2024-11-13
Locations
1 site across 1 country: Switzerland
Source: ClinicalTrials.gov record NCT03336658. Inclusion in this directory is not an endorsement.