NCT03336086

Effect of Weight Reduction on Immunity

Reduction of Natural Killer Cell (CD16/56) and T-lymphocyte (CD3) Subset Counts After a Weight Loss Program Using Anti-obesity Drugs in Obese Women: a Non-randomized Controlled Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: Shiraz University of Medical Sciences · Academic / Other
• Sex: Female
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.

Detailed description

TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity

Conditions

• Lymphocytes
• Weight Loss
• Viral Diseases
• Immunity
• Anti-obesity Agents

Interventions

Type	Name	Description
COMBINATION_PRODUCT	weight loss program	A low calorie diet+ Orlistat+ Soluble Fiber+ Physical activity

Timeline

• Start date: 2012-03-20
• Primary completion: 2012-11-30
• Completion: 2012-12-25
• First posted: 2017-11-08
• Last updated: 2017-11-08

Regulatory

• FDA-regulated drug study
• FDA-regulated device study