NCT03335137

Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 35 (actual)
• Sponsor: University Hospital Schleswig-Holstein · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.

Conditions

• Antibiotics
• Severe Burn
• Intensive Care

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Drug Level Monitoring	Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission

Timeline

• Start date: 2014-05-01
• Primary completion: 2016-05-31
• Completion: 2016-12-31
• First posted: 2017-11-07
• Last updated: 2017-11-07

Locations

1 site across 1 country: Germany