NCT03333564

Effect of Vitamin D3 and Omega-3FA on Estradiol

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (actual)
• Sponsor: Applied Science Private University · Academic / Other
• Sex: Female
• Age: 22 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The effect of vitamin D3 and omega-3 Fatty acids on estradiol levels.

Detailed description

The data about effect of vitamin D3 (VD3) and omega-3 fatty acids (omega-3FA) on serum levels of estradiol (E2) are scarce and conflicting and nothing is published in the literature about the effect of the combination of VD3 and omega-3FA on the E2 levels. This study was conducted to investigate effect of VD3 and omega-3FA alone and with each other on serum E2 levels in premenopausal females with vitamin D deficiency (VDD). This randomized, placebo-controlled clinical trial was designed to test effects of 50,000 IU VD3 weekly and 300 mg omega-3FA daily for eight weeks, separately and with each other, on the mid-follicular serum levels of E2 and 25-hydroxy vitamin D (25OHD). This study was conducted during winter in 86 healthy premenopausal Jordanian females with VDD with a mean age of (32.8 ± 8.9) years. Fasting serum levels for 25OHD, E2, PTH (parathyroid hormon), calcium, phosphate, ALT (alanine aminotransferase), and urea were assessed at baseline and the end of the trial.

Conditions

• Vitamin D Deficiency

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	VD3	50,000 IU VD3 / week for 8 weeks
DIETARY_SUPPLEMENT	Omega3-FA	300 mg of omega3-FA once daily for 8 weeks
DIETARY_SUPPLEMENT	VD3 and Omega-3FA	50,000 IU VD3 / week for 8 weeks and 300 mg of omega-3FA once daily for 8 weeks
OTHER	Control	No intervention was given

Timeline

• Start date: 2016-11-01
• Primary completion: 2017-02-01
• Completion: 2017-02-01
• First posted: 2017-11-07
• Last updated: 2017-11-07