NCT03332602

Iron Absorption From Encapsulated Iron Sulphate in Microspheres

The Effect of Encapsulation Material and Encapsulated Micronutrients on Iron Absorption in Iron Depleted Women Consuming Iron Fortified Bread.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Swiss Federal Institute of Technology · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Food fortification has shown to be efficacious to alleviate the burden of micronutrient deficiencies. Ensuring the bioavailability of iron and maintaining the sensory quality and stability of the fortified food and other added micronutrients remains a challenge. Soluble iron compounds cause minor organoleptic changes in foods but their bioavailability in man is rather low. Water-soluble iron compounds, such as ferrous sulphate (FeSO4), are the compounds in which the iron is most bioavailable; however, they often cause unfavorable sensory changes. Encapsulation of iron has excellent potential for overcoming unwanted sensory changes and iodine losses in salt, while maintaining acceptable bioavailability. In the present project, we would like to investigate the iron bioavailability from a new formulation of encapsulated iron sulphate based on hyaluronic acid (HA) and a polymer from the eudragit family.

Conditions

• Iron-deficiency

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	free FeSO4	Testmeal with free FeSO4
DIETARY_SUPPLEMENT	free FeSO4 and empty microspheres	Testmeal with free FeSO4 and empty micropsheres
DIETARY_SUPPLEMENT	free FeSO4 and hylauronic acid	Testmeal with free FeSO4 and hyaluronic acid
DIETARY_SUPPLEMENT	free FeSO4 and eudragit polymer	Testmeal with free FeSO4 and eudragit polymer
DIETARY_SUPPLEMENT	encapsulated FeSO4 3.2%	Testmeal with encapsulated FeSO4 with 3.2% Fe loading
DIETARY_SUPPLEMENT	encapsulated FeSO4 20%	Testmeal with encapsulated FeSO4 with 20% Fe loading
DIETARY_SUPPLEMENT	encapsulated FeSO4 3.2%, encapsulated Vitamin A	Testmeal with encapsulated FeSO4 with 3.2% Fe loading, and encapsulated Vitamin A
DIETARY_SUPPLEMENT	encapsulated FeSO4 3.2%, encapsulated Vitamin A, free Folic Acid	Testmeal with encapsulated FeSO4 with 3.2% Fe loading, and encapsulated Vitamin A, with free folic acid.
DIETARY_SUPPLEMENT	FeSO4 embedded in Hyaluronic acid	Testmeal with FeSO4 embedded in Hyaluronic acid

Timeline

• Start date: 2018-04-04
• Primary completion: 2018-07-18
• Completion: 2018-08-20
• First posted: 2017-11-06
• Last updated: 2018-08-31

Locations

1 site across 1 country: Switzerland