Trials / Terminated
TerminatedNCT03331861
Metformin in Heart Failure Without Diabetes
- Status
- Terminated
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 6 (actual)
- Sponsor
- Columbia University · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
A pilot clinical research study that will assess the use of the medication metformin for heart failure in patients who are not diabetic and have no evidence of insulin resistance.
Detailed description
Patients (n=50) will received either the study drug metformin or placebo for 4 months. During the study, the patients will undergo extensive testing that will include symptom assessment, exercise capacity, echocardiography, cardiac PET imaging and blood tests.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metformin hydrochloride | Metformin starting at 500mg twice a day and increasing to 1000mg twice a day for a total of 6 months |
| DRUG | Placebo | Similar dosing regime as active comparator |
Timeline
- Start date
- 2019-02-15
- Primary completion
- 2021-08-20
- Completion
- 2021-08-20
- First posted
- 2017-11-06
- Last updated
- 2024-07-18
- Results posted
- 2024-07-18
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03331861. Inclusion in this directory is not an endorsement.