Trials / Completed
CompletedNCT03331432
Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function
Targeting Endoplasmic Reticulum Stress to Correct Vascular Insulin Resistance and Glycemic Dysregulation
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 8 (actual)
- Sponsor
- University of Missouri-Columbia · Academic / Other
- Sex
- All
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of the present study is to determine if use of dietary supplement tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
Detailed description
The notion that cellular stress lowers insulin-induced vasodilation is largely founded on ex vivo studies and experiments in rodents. However, it remains unknown if maintenance of cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances vascular function in humans. The investigators test the hypothesis that daily administration of this dietary supplement enhances vascular function, particularly, insulin-stimulated leg blood flow and glucose disposal.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Tauroursodeoxycholic acid | Taking tauroursodeoxycholic acid (1750 mg/day) capsules for 4 weeks. |
| DIETARY_SUPPLEMENT | Placebo | Taking daily placebo capsules for 4 weeks. |
Timeline
- Start date
- 2015-10-28
- Primary completion
- 2017-08-15
- Completion
- 2018-02-14
- First posted
- 2017-11-06
- Last updated
- 2018-02-19
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03331432. Inclusion in this directory is not an endorsement.