NCT03329105

Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health

Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health in a Group of Young Adults: A Pilot Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: All
• Age: 20 Years – 26 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the addition of a mouth rinse containing sea salt, xylitol and lysozyme to standardized oral health practices on biofilm formation and gingival health in a group of young adults.

Detailed description

The purpose of this study is to evaluate a new sea salt mouth rinse containing xylitol and the antibacterial enzyme, lysozyme on biofilm formation and gingival health in a group of young adults. Xylitol is a well-established non-sugar sweetener and an anti-caries agent. The use of this polyol results in loosely adherent biofilms by reducing the amount of extracellular lipopolysaccharides and lipoteichoic acids, facilitating its easy removal by mechanical means. Lysozymes are antibacterial proteins that hydrolyze the linkage between N-acetylmuramic acid and N-acetylglucosamine of peptidoglycan in the cell wall of Gram + bacteria effectively limiting growth.

Conditions

• Chronic Gingivitis
• Chronic Gingivitis, Plaque Induced

Interventions

Type	Name	Description
OTHER	Sea Salt Mouth Rinse	Rinsing mouth with a tablespoon of sea salt mouth rinse without any dilution, for 30 seconds, once in the morning and once before bed, in addition to Standardized Oral Health Practices.
OTHER	Standardized Oral Health Practices	Brushing teeth for two minutes using the modified Bass technique, twice per day with the provided dentifrice, and flossing once daily using the spool method

Timeline

• Start date: 2016-11-07
• Primary completion: 2017-08-24
• Completion: 2017-08-24
• First posted: 2017-11-01
• Last updated: 2017-11-01

Locations

1 site across 1 country: Canada