NCT03328377

The Gut Microbiota and Delirium in the ICU

The Association Between the Gut Microbiota Composition and Development of Delirium in ICU Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Herlev Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.

Detailed description

We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative. Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.

Conditions

• Delirium of Mixed Origin
• Microbial Colonization

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Metagenomic analysis of gut microbiota	All patients have rectal swaps/fecal samples subjected to metagenomic analysis

Timeline

• Start date: 2017-11-01
• Primary completion: 2018-02-28
• Completion: 2018-05-31
• First posted: 2017-11-01
• Last updated: 2017-11-01