NCT03326505

Allogenic Mesenchymal Stem Cells And Physical Therapy for MS Treatment

The Effect of Stem Cell Therapy and Comprehensive Physical Therapy in Motor and Non-Motor Symptoms in Patients With Multiple Sclerosis: A Comparative Study.

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University of Jordan · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims at expanding Umbilical Cord derived Mesenchymal Stem Cells (MSCs) to a clinical scale according to Good Laboratory Practice and study its efficacy when compared to a Supervised Physical Therapy Program alone.

Detailed description

Umbilical cord derived MSCs bank will be generated and all patients given the same cells from the same biological sample. Thorough clinical, cognitive and motor analysis will be performed at baseline and compared to outcomes at 3 different time points of all enrolled patients. The study will consist of three arms: 1- Stem cells treatment 2- Stem cells and supervised physical therapy 3- Supervised physical therapy

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
BIOLOGICAL	Umbilical cord derived Mesenchymal Stem Cells	Allogenic umbilical cord derived stem cells which are to be injected intrathecally as a treatment option for consenting MS patients
OTHER	Supervised physical therapy	A combined physical therapy program of Balance, strengthening and endurance exercises

Timeline

• Start date: 2017-09-25
• Primary completion: 2020-01-25
• Completion: 2020-02-20
• First posted: 2017-10-31
• Last updated: 2020-03-04

Locations

2 sites across 1 country: Jordan