NCT03325569

GLP-1 Response in Women With PCOS and Prediabetes

Reduced GLP-1 Response is Associated With Prediabetes in Women With Adverse Metabolic Phenotype of PCOS Independently of BMI

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University Medical Centre Ljubljana · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Women with PCOS are more prone to obesity which exacerbates insulin resistance, the abdominal fat disposition and metabolic risk of these patients. With development of obesity these women have high conversion rate from normal glucose tolerance to impaired glucose tolerance and in turn to type 2 diabetes. Glucagon-like peptide 1 (GLP-1) is involved in body weight maintenance. Beside energy balance it is also involved in glucose homeostasis. Functional deficit in GLP-1 facilitates obesity. We investigated the link between the concentration of incretin hormones and glucose homeostasis, metabolic complications and the distribution of body composition in obese women with PCOS.

Conditions

• Incretin Hormones in PCOS With Prediabetes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	oral glucose tolerance test	GLP1 response to oral glucose load during oral glucose tolerance test was assessed.

Timeline

• Start date: 2017-02-13
• Primary completion: 2017-03-27
• Completion: 2017-03-27
• First posted: 2017-10-30
• Last updated: 2017-10-30

Locations

1 site across 1 country: Slovenia