NCT03325491

Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance

Assessing the Effects of Increased Mitochondrial Function and Chronic Aerobic or Resistance Exercise Training on Skeletal Muscle Performance in Older Men; a Pilot Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: Male
• Age: 65 Years – 75 Years
• Healthy volunteers: Accepted

Summary

As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability of muscle to perform physical activity. There is some evidence that supplements may improve how the mitochondria work, and investigators want to explore this idea in more detail. This is possible by measuring how the muscles work and respond to exercise before and after taking the supplement alongside an aerobic (i.e. cycling) and resistance (i.e. weight lifting) exercise programme. This will give us the basic information investigators would need to see if this is a useful idea.

Conditions

• Impaired Mitochondrial Function, Muscle Performance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Acipimox	Acipimox plus exercise training: Oral supplement containing Acipimox 250mgs as the active ingredient in blinded label tablet form.
DIETARY_SUPPLEMENT	Placebo	Alternate unilateral resistance and aerobic exercise training will also be performed 5 times per week for 6 weeks.

Timeline

• Start date: 2018-03-07
• Primary completion: 2019-09-16
• Completion: 2019-09-16
• First posted: 2017-10-30
• Last updated: 2019-09-27

Locations

1 site across 1 country: United Kingdom