NCT03321942

Treatment of Chronic Renal Failure With Adipose Tissue-derived Mesenchymal Stem Cells

The Biological Characteristics of Adipose Tissue-derived Mesenchymal Stem Cells and Its Role in the Treatment of Chronic Renal Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: The Affiliated Hospital of Xuzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its treatment effects on chronic renal failure.

Detailed description

This study aims to investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its effect on oxidative stress, inflammation and mitochondrial damage.We intend to use blood oxygen level-dependent magnetic resonance imaging(BOLD-MRI), emission computed tomography(ECT) and enhanced magnetic resonance imaging to monitor renal oxygenation, tissue perfusion and renal function.Ultimately, we evaluate the treatment effects of AMSCs on chronic renal failure through these observations mentioned above.We hope to delay the progression of renal function in patients with chronic renal failure, and save huge social cost for dialysis by these research.

Conditions

• Mesenchymal Stem Cells
• Chronic Kidney Diseases
• Renal Interstitial Fibrosis

Interventions

Type	Name	Description
DRUG	Treatment group	Adipose tissue-derived mesenchymal stem cells were used to treat patients with chronic renal failure on the basis of conventional treatment.
DRUG	Control group	Conventional treatment were used to treat patients with chronic renal failure.

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2017-10-26
• Last updated: 2017-10-26

Locations

1 site across 1 country: China