NCT03321708

Respiratory Microbiome in COPD and Associated Inmune Response.

Respiratory Microbiome in COPD. Relationship With Systemic and Pulmonary Inmune Response.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Hypothesis: COPD patients with frequent exacerbations have different pulmonary and systemic immune response than COPD patients without frequent exacerbations and this is related to their microbiome.

Detailed description

The objective of this project is to determine the pulmonary microbiome and its relationship with the pulmonary and systemic inmune response in COPD patients with frequent (FE) and non frequent exacerbations (NE). 1. The pulmonary immune response. -The role of mucins, antimicrobial peptides (AMPs), Matrix metalloproteinases (MMPs) and Toll-like receptors (TLRs) as lung defense mechanisms and their possible relationship with the microbiome in COPD and FE patients. 2. The systemic immune response. -The pulmonary and blood inflammatory response and circulating bacterial products as markers of the systemic immune response.

Conditions

• Pulmonary Disease (COPD), Chronic Obstructive

Timeline

• Start date: 2016-03-01
• Primary completion: 2018-03-01
• Completion: 2018-12-01
• First posted: 2017-10-26
• Last updated: 2017-10-26

Locations

1 site across 1 country: Spain