NCT03318913

Vascular Function, Fish Protein Hydrolysates and Type 2 Diabetes Mellitus

Effect of Acute Fish Protein Hydrolysates Ingestion on Vascular Function of the Type 2 Diabetes Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Universidade Federal do Rio de Janeiro · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease of abnormal carbohydrate metabolism which is related with high morbidity and mortality rates caused by its complications. One of the major diabetes-related arterial phenotypes thought to be responsible for development of cardiovascular disease is endothelial dysfunction. Nitric oxide (NO) is a potent molecule derived of endothelium, which plays key role in control of vascular tone. In T2DM present endothelial dysfunction due to reduced NO bioavailability. Fish protein hydrolysates (FPH) have been showed to present antioxidant peptides (and high value of ACE inhibition activity. Therefore, the present study aimed to examine whether single dose of FPH ingestion would reversal macro- and microvascular endothelial dysfunction in T2DM.

Conditions

• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
OTHER	Placebo	5g of the sucralose administered as white plastic capsules
OTHER	Fish protein hydrolysates	5g of the FPH dissolving in 100 mL of water

Timeline

• Start date: 2017-10-23
• Primary completion: 2018-02-15
• Completion: 2018-03-28
• First posted: 2017-10-24
• Last updated: 2019-12-13

Locations

1 site across 1 country: Brazil