NCT03315234

Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease

Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease in the Greek Population

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 270 (actual)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score). The aim of the study is to combine genetic, clinical and laboratory data in order to create a prognostic tool that will enable an individualized therapeutic patient approach.

Detailed description

This study focus on the prediction of future risk of cardiovascular events, assessing the severity and complexity of coronary artery disease by incorporating genetic information into the SYNTAX score and providing personalized therapeutic guidance to patients. The ultimate goal of the study would be to identify, design and develop a panel of genetic markers that in combination with clinical and angiographic information will be a reliable tool for predicting cardiovascular risk for future adverse events. Clinical and genetic patient information are systematically collected in a fashion that will enable also retrospective evaluation.

Conditions

• Coronary Artery Disease
• Cardiovascular Risk Factor
• Coronary Arteriosclerosis

Interventions

Type	Name	Description
GENETIC	SNPs associated with CAD	Genotyping will be carried out by Real-Time PCR

Timeline

• Start date: 2016-09-01
• Primary completion: 2018-06-30
• Completion: 2021-06-30
• First posted: 2017-10-20
• Last updated: 2020-06-09

Locations

1 site across 1 country: Greece