NCT03314506

Adipose Tissue Cellular Response to Exercise in Healthy Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to measure the effects of a single session of exercise on changes in the cellular composition of the body fat of humans.

Detailed description

Fat tissue is far more than just a place where humans store body fat. Fat tissue contains many different types of cells, such as immune cells, endothelial cells, and fat precursor cells. Differences or changes in the number of immune cells, endothelial cells, and fat precursor cells in fat tissue can have a great impact on metabolic health. The abundance of all immune cells, endothelial cells, and fat precursor cell types are known to change when a person loses or gains weight. For example, the abundance of inflammatory cells is often found to decrease markedly with weight loss - and this change has been linked to the profound improvements in metabolic health that occur with weight loss. In contrast, the effects of exercise on immune cells, endothelial cells, and fat precursor cells in fat tissue is not known. Determining the effects of exercise on changes in the cellular composition within fat tissue will provide important information for optimizing lifestyle interventions aimed at improving metabolic health.

Conditions

• Metabolic Disease
• Adipose Tissue

Interventions

Type	Name	Description
OTHER	Exercise	Subjects will exercise on a treadmill for 1 hour at a moderate intensity (approximately 70% of their predicted VO2peak).

Timeline

• Start date: 2017-11-01
• Primary completion: 2019-08-08
• Completion: 2019-08-08
• First posted: 2017-10-19
• Last updated: 2022-03-21

Locations

1 site across 1 country: United States