NCT03309618

Post- Myocardial Infarction Arterial Wall Improvement by Low-dose Fluvastatin and Valsartan

Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan: Proof-of-concept Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: University Medical Centre Ljubljana · Academic / Other
• Sex: Male
• Age: 55 Years
• Healthy volunteers: —

Summary

The concept of improving arterial wall characteristics by treatment with a very low-dose combination of fluvastatin and valsartan (low-flu/val) in stable, post-myocardial infarction (MI) patients was tested. The parameters of endothelial function (flow mediated dilatation (FMD), reactive hyperemia index) and arterial stiffness (carotid-femoral pulse wave velocity (cf-PWV), local carotid PWV and β-stiffness coefficient) were measured before and after 30 days of treatment, and the residual effect was assessed 10 weeks later. So the investigators explored whether low-flu/val added "on-top-of" optimal therapy could improve endothelial function and arterial stiffness in post-MI patients. Since these improved parameters are well-known predictors of future coronary events, such treatment could decrease cardiovascular risk.

Conditions

• Myocardial Infarction

Interventions

Type	Name	Description
DRUG	low-dose combination of fluvastatin (10 mg) and valsartan (20 mg) (low-flu/val)
DRUG	placebo

Timeline

• Start date: 2012-11-01
• Primary completion: 2013-11-01
• Completion: 2014-11-01
• First posted: 2017-10-13
• Last updated: 2017-10-16

Locations

1 site across 1 country: Slovenia