NCT03309579

SAHaRA: A Randomized Controlled Trial

Aneurysmal Subarachnoid Hemorrhage - Red Blood Cell Transfusion and Outcome (SAHaRA): A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 742 (actual)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The SAHaRA trial will clarify the role of treating anemia with Red Blood Cell (RBC) transfusion in a unique and vulnerable patient population, and determine whether that impacts on functional outcomes and mortality. It will guide best practice standards and clarify the optimal RBC transfusion strategy in patients with aSAH.

Detailed description

We hypothesize that in adult patients suffering from aSAH and anemia, a liberal RBC transfusion strategy as compared to a restrictive RBC transfusion strategy decreases the combined rate of death and severe disability at 12 months (using the modified Rankin Scale)

Conditions

• Subarachnoid Hemorrhage, Aneurysmal

Interventions

Type	Name	Description
OTHER	Liberal RBC Transfusion Strategy	RBC transfusion is triggered by a Hemoglobin value of ≤100g/L
OTHER	Restrictive RBC Transfusion Strategy	Optional RBC transfusion is triggered by a Hemoglobin value of ≤80g/L

Timeline

• Start date: 2018-02-12
• Primary completion: 2024-07-10
• Completion: 2024-08-22
• First posted: 2017-10-13
• Last updated: 2024-11-06

Locations

23 sites across 3 countries: United States, Australia, Canada