NCT03309436

Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 360 (estimated)
• Sponsor: ShangHai Ji Ai Genetics & IVF Institute · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Clomiphene citrate has been widely used for treatment of infertility for decades. Although its anti-estrogenic effects leads to low pregnancy rate, clomiphene citrate is still a first-line treatment for ovulation induction because of its simple usage, low prices, no injection and low risk of ovarian hyperstimulation syndrome. Clomiphene citrate shows high affinity with estrogen receptor, which inhibits endometrial proliferation, inevitably leads to a decline in endometrial receptivity, thus affecting the success rate of IVF. In that case, use clomiphene citrate for ovulation induction is lost more than gained based on fresh embryo transfer. But recently, some researchers have proposed to extend the time from ovulation induction to embryo transfer, and the increased level of estradiol can replace clomiphene citrate to combine with the receptor, so that the uterine environment is more conducive to pregnancy. Therefore, use clomiphene citrate based on vitrification of embryo maybe a good way for treatment of infertility. At present, using frozen embryo transplantation after ovulation induction by clomiphene citrate is a common treatment, but few research has mentioned the best time for embryo implantation. The investigators research is to find the most appropriate time for frozen embryo implantation after using clomiphene citrate for ovulation induction.

Detailed description

This study receives patients from 2017 August to 2018 June who undergo ART treatment at Shanghai Jiai Genetics \& IVF Institute and taken either CC or GnRH antagonist protocol(control group) for ovulation induction. The investigators will record every patients' age, BMI, serum E2, P, LH level, infertility factors and pregnancy outcomes, counted the implantation rate and clinical pregnancy rate, and then used SPSS Software x2 test for statistical analysis, the significance was set at p\<0.05.The investigators will also make a correlation analysis about the serum hormone level and pregnancy outcomes.

Conditions

• Infertility, Female
• Clomiphene Citrate

Interventions

Type	Name	Description
DRUG	Clomiphene Citrate protocol	Take CC 100mg/d at the same time with Gn until hCG injection.
PROCEDURE	Procedure	When a dominant follicle diameter over 14mm or serum E2 over 350pg/ml, use GnRH-ant 0.25mg/d, until hCG injection.

Timeline

• Start date: 2017-08-07
• Primary completion: 2018-06-30
• Completion: 2018-06-30
• First posted: 2017-10-13
• Last updated: 2017-10-13

Locations

1 site across 1 country: China