NCT03306017

Effects of Left Ventricular Assist Device Implantation on the Phenotype of Blood Platelets and Leucocytes

Study on the Effects of Left Ventricular Assist Device Implantation on the Phenotype of Blood Platelets and Leucocytes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation

Detailed description

The present study plan to investigate platelet activation in vivo using a variety of biomarkers previously identified as sensitive to high shear stress in patients with severe aortic valve stenosis before and after trans arterial valve replacement. As one of the best biomarker is a high degree of platelet-leukocyte interactions, the study will study in parallel leukocytes activation/differentiation. These parameters will be compared at 3 time-points, before and after LAVD implantation in ambulatory patients.

Conditions

• Cardiac Insufficiency

Interventions

Type	Name	Description
OTHER	Blood sampling	Three venous blood sampling before the left ventricular assist device implantation and 1 and 2 months after implantation in ambulatory patients.

Timeline

• Start date: 2017-10-03
• Primary completion: 2018-08-23
• Completion: 2019-01-23
• First posted: 2017-10-10
• Last updated: 2019-08-20

Locations

1 site across 1 country: France