NCT03305536

Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7)

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Hopital St. Georges, Ajaltoun · Academic / Other
• Sex: All
• Age: 30 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Aortic Stenosis is a common but fatal disease when it becomes symptomatic, specially if not treated. Until now surgery remains the only reliable and effective treatment. In this study, the investigators will examine the effect of high dose of Menaquinone-7 (MK-7) supplementation (1000 mcg)/day on the progression of the aortic valve disease. The investigators hypothesize that MK-7 supplementation may slow or even reverse the progression of the disease process.

Detailed description

The study is a randomized clinical trial that will use Cardiac Echography and multi-detector computed tomography to compare the changes in the Aortic Valve Calcification Score (AVCS) over 3 years when using: 1. 1000 mcg/d Vitamin K2 (menaquinone-7) + 5000 IU/d Vitamin D3 2. 5000 IU/d Vitamin D3 as a control group

Conditions

• Aortic Valve Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin K2 (Menaquinone 7) + Vitamin D3	Vitamin K2 + Vitamin D3 arm will be compared with Vitamin D3 arm to slow of reverse the progression of the disease

Timeline

• Start date: 2018-01-02
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2017-10-10
• Last updated: 2019-08-09

Locations

1 site across 1 country: Lebanon