NCT03304262

Metaplasticity Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

Metaplasticity in the Human Motor Cortex: Validation of an Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of New Mexico · Academic / Other
• Sex: Female
• Age: 18 Years – 99 Years
• Healthy volunteers: Accepted

Summary

The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants.

Detailed description

The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants. Our primary objective is to compare pre- and post-measures of cortical excitability before priming tDCS (anodal, cathodal or sham) \[M1\], directly after priming tDCS \[M2\], directly after inhibitory rTMS \[M3\], and 10 minutes after inhibitory rTMS \[M4\]. Our secondary objective is to evaluate the sensitivity of motor excitability outcome measures response to the noninvasive neurostimulation (e.g. rTMS and tDCS). We also aim to compare pre- and post- measures of cortical excitability after inhibitory and excitatory priming of the motor cortex, and to evaluate the sensitivity of motor outcome measures to changes in cortical plasticity.

Conditions

• Healthy

Interventions

Type	Name	Description
DEVICE	rTMS	Between time point M2 and M3, participant will receive 900 pulses of rTMS at 1Hz at 0.85 of M2 resting motor threshold.

Timeline

• Start date: 2017-07-18
• Primary completion: 2018-02-28
• Completion: 2018-03-31
• First posted: 2017-10-06
• Last updated: 2023-08-25
• Results posted: 2023-08-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study