NCT03303729

Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)

Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption kinetics of protein-derived amino acids and the impact on myofibrillar protein synthesis. During the trial days the subjects will perform a bout of whole body resistance exercise and ingest a supplement of meat hydrolysate labeled with D5-phenylalanine together with randomized and double blinded type of carbohydrate consisting of either glucose or cluster dextrin. The primary outcome is the time to obtain peak concentration of D5-phenylalanine after intake of meat hydrolysate with either glucose or cluster dextrin. Hypotheses: I) The cluster dextrin will increase the absorption of the amino acids from the meat hydrolysate, and thereby result in a faster rise and a higher peak in plasma amino acid concentration in the postprandial period. II) The meat hydrolysate will increase the protein synthesis rate to a higher extent when combined with cluster dextrin than with glucose.

Conditions

• Muscle Protein Synthesis
• Amino Acid

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Meat Hydrolysate	25 grams of meat hydrolysate to maximally stimulate protein synthesis.
DIETARY_SUPPLEMENT	Cluster Dextrin	75 grams of Cluster Dextrin
DIETARY_SUPPLEMENT	Placebo	75 grams of Glucose

Timeline

• Start date: 2017-11-24
• Primary completion: 2018-02-23
• Completion: 2018-02-23
• First posted: 2017-10-06
• Last updated: 2018-02-27

Locations

1 site across 1 country: Denmark