Trials / Completed
CompletedNCT03303573
Safety and Efficacy of Multiple EPO Injections in Children With Cerebral Palsy
Safety and Efficacy of Repetitive Erythropoietin Treatment for Cerebral Palsy
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 164 (actual)
- Sponsor
- Bundang CHA Hospital · Academic / Other
- Sex
- —
- Age
- —
- Healthy volunteers
- —
Summary
This study is a retrospective review on the safety and efficacy of repetitive erythropoietin injection in children with cerebral palsy
Detailed description
Cerebral palsy is mostly caused by hypoxic-ischemic encephalopathy from preterm birth, involving inflammatory and apoptotic cellular response. Erythropoietin (EPO) has shown neuroprotective effects via activation of anti-inflammatory, angiogenic, and anti-apoptotic pathways. The safety and feasibility of EPO in children were proven in previous clinical trials. In addition, the efficacy of EPO is actively being investigated and some reports have shown potential benefits in cerebral palsy. To confirm the safety and efficacy of multiple injections with expected effect, retrospective review on medical records was performed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | recombinant human erythropoietin | Subcutaneous rhEPO injection |
Timeline
- Start date
- 2013-01-01
- Primary completion
- 2016-11-30
- Completion
- 2017-08-01
- First posted
- 2017-10-06
- Last updated
- 2017-10-10
Source: ClinicalTrials.gov record NCT03303573. Inclusion in this directory is not an endorsement.