NCT03300726

Synaptic Injury and Functional Connectivity in Alzheimer's Disease

Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer's Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 35 (actual)
• Sponsor: Ohio State University · Academic / Other
• Sex: All
• Age: 60 Years – 95 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with MCI (i.e. the earliest clinically detectable stage of cognitive impairment) due to AD or mild AD dementia (CDR 0.5-1; n=20) and cognitively normal controls (CDR 0; n=20).

Detailed description

SPECIFIC AIMS: Aim 1: Investigate correlations between CSF biomarkers of synaptic injury (Ng and SNAP-25) and functional connectivity (FC) within the default mode network (DMN) using resting-state fMRI (adjusting for age, gender, apolipoprotein-E4 \[APOE4\] genotype, task performance, and regional brain atrophy) in MCI/AD and controls. Aim 2: Examine correlations between CSF biomarkers of synaptic injury and functional connectivity (FC) within the semantic memory network on task-activated fMRI using the Famous Name Discrimination Task (FNDT) (adjusting for age, gender, APOE4 genotype, task performance, and regional brain atrophy) in MCI/AD and controls.

Conditions

• Alzheimer Disease, Late Onset

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CSF analysis	CSF analysis for tau, p-tau181, Abeta42, and CSF levels of markers of synaptic injury
RADIATION	Functional MRI	Functional MRI during resting state and semantic memory task activation

Timeline

• Start date: 2018-02-12
• Primary completion: 2021-09-22
• Completion: 2021-09-22
• First posted: 2017-10-03
• Last updated: 2021-09-28

Locations

1 site across 1 country: United States