NCT03299972

Multidisciplinary Research Into the Effects of Resistance Exercise and Whey Protein Supplementation in Healthy Older Men

Effects of 12 Weeks Resistance Exercise and Whey Protein Supplementation on Energy Metabolism, Appetite, Body Composition and Biomarkers Related to Sarcopenia and Metabolic Health

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Coventry University · Academic / Other
• Sex: Male
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of this randomised, double-blind, placebo-controlled, parallel groups trial is to investigate the effects of 12 weeks resistance exercise and whey protein supplementation on energy metabolism, markers of appetite, inflammation and hormonal response and body composition and strength and functional performance. Generally healthy, retired men aged 60-80 years will be recruited (n = 52 in total, n = 13 per group). Participants will be randomised to either: a) control group, b) whey protein supplement group, c) resistance exercise + control group or d) resistance exercise + whey protein supplementation group.

Detailed description

With demographics indicating that the world's population aged \>60 years will increase from 600 million reported in 2000, to \>2 billion by 2050, there is an increasing interest in health issues related to ageing. One area of particular interest is sarcopenia, defined as the progressive loss of muscle mass, strength and physical function as a consequence of ageing. Sarcopenia has been associated with an increase in cardiovascular disease, poor metabolic and cognitive function, reduced quality of life and early mortality. Studies have reported beneficial effects of both resistance exercise and increasing protein intake independently and in combination on markers of sarcopenia (mostly increases in muscle mass, strength and physical function). However, little is known about the effects of combined intervention on energy metabolism, appetite and cognitive and endocrine function. This randomised, double-blind, placebo-controlled, parallel groups trial will investigate these, alongside assessing the effects of combined intervention on total lean tissue mass, muscular strength and functional performance.

Conditions

• Sarcopenia
• Muscle Atrophy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey Protein	25 g whey protein supplementation twice daily (breakfast and lunch)
DIETARY_SUPPLEMENT	Control	23.75 g maltodextrin twice daily (breakfast and lunch)
OTHER	Resistance Exercise	60 minutes of resistance exercise twice a week

Timeline

• Start date: 2017-10-27
• Primary completion: 2019-06-30
• Completion: 2019-06-30
• First posted: 2017-10-03
• Last updated: 2019-07-26

Locations

1 site across 1 country: United Kingdom