NCT03297996

Study of Gut Microbiome and Colorectal Tumors

The Gut Microbiota in Conventional and Serrated Precursors of Colorectal Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 540 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.

Detailed description

Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. A relationship between the human gut microbiota and colorectal cancer has been shown; however, its relationship to the different early precursors of colorectal cancer is understudied. This study tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.

Conditions

• Serrated Polyp
• Hyperplastic Polyp
• Sessile Serrated Adenoma
• Colorectal Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Mobio PowerSoil DNA Isolation Kit	16S rRNA amplicons covering variable regions V3 to V4 were generated using primers (347F-5'GGAGGCAGCAGTRRGGAAT'-3' and 803R 5'-CTACCRGGGTATCTAATCC-3') incorporating Roche 454 FLX Titanium adapters (Branford, CT) and a sample barcode sequence

Timeline

• Start date: 2011-11-23
• Primary completion: 2015-04-25
• Completion: 2015-04-25
• First posted: 2017-09-29
• Last updated: 2017-09-29

Locations

1 site across 1 country: United States