NCT03297073

Paracetamol Metabolism Research in Postoperative Hepatic Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study was to evaluate the 5-day kinetics of plasma paracetamol levels in postoperative major hepatic surgery (resection greater than or equal to three hepatic segments) compared with less extensive liver resection and hepatic re-intervention. The clearance of indocyanine green is a marker of hepatic perfusion but also of the proper hepatocyte functioning, if hemodynamic conditions are stable. Some patients may be operated on up to four or five times in the liver. Moreover, these patients probably present an increased risk of postoperative hepatocellular insufficiency due to a quantitative and qualitative decrease in their hepatic parenchyma. It is therefore interesting to evaluate the use of paracetamol in this situation.

Conditions

• Paracetamol Causing Adverse Effects in Therapeutic Use
• Hepatic Disease

Interventions

Type	Name	Description
DRUG	paracetamol	Paracetamol 1000 mg will be administered 30 minutes before the end of the procedure and then every 6 hours systematically at the following times: 6h / 12h / 18h / 00h. The analgesic treatment after hepatectomy with paracetamol will be maintained for at least 5 days in all patients in parenteral form
PROCEDURE	hepatic surgery

Timeline

• Start date: 2016-11-20
• Primary completion: 2018-04-01
• Completion: 2019-11-01
• First posted: 2017-09-29
• Last updated: 2025-12-23

Locations

1 site across 1 country: France