NCT03295448

Fatty Acid Biomarkers of Carbohydrate Intake

Circulating Fatty Acids as Biomarkers of Dietary Carbohydrates: a Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Detailed description

In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.

Conditions

• Dyslipidemias

Interventions

Type	Name	Description
OTHER	Low carbohydrate diet	Diet low in carbohydrates (38%E), but higher in total and saturated fat.
OTHER	High carbohydrate, high sugar diet	Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.
OTHER	High carbohydrate, low sugar diet	Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Timeline

• Start date: 2017-10-25
• Primary completion: 2018-06-01
• Completion: 2018-06-01
• First posted: 2017-09-27
• Last updated: 2018-11-15

Locations

1 site across 1 country: Sweden