NCT03293446

AC/DC Study: Acidification Test in Patients With Chronic Kidney Disease and Healthy Controls

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 99 Years
• Healthy volunteers: Accepted

Summary

In this study the effect of an acute acid load on the intrarenal renin angiotensin-system is evaluated in patients with chronic kidney disease and healthy controls

Detailed description

Metabolic acidosis is one of the metabolic complications of chronic kidney disease (CKD). Correction of metabolic acidosis in CKD has been shown to prevent further loss of kidney function over time. Currently, a clinical trial (the BIC-study, MEC-2013-332) is conducted in which patients with CKD and metabolic acidosis receive sodium bicarbonate, sodium chloride, or no treatment (time control) to address the hypothesis that the beneficial effects of acidosis correction are mediated through inhibition of the intrarenal renin-angiotensin system (RAS). It is unknown, however, if and how acute changes in acid-base status affect the intrarenal RAS during CKD. In the present study it is hypothesized that an acute acid load increases the activity of the intrarenal RAS, and that this response is exaggerated in patients with CKD compared with healthy controls.

Conditions

• Chronic Kidney Disease stage4

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Urinary acidification test	Urinary acidification by administration of ammonium chloride (100 mg/kg body weight, given orally) during a single-day hospital admission.

Timeline

• Start date: 2016-10-07
• Primary completion: 2018-11-11
• Completion: 2018-11-11
• First posted: 2017-09-26
• Last updated: 2019-06-20

Locations

1 site across 1 country: Netherlands