NCT03291210

O2 Tension During TAVI

Effect of O2 Tension on Myocardial Injury During TAVI

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Hyperoxemia can produce various complications including oxidative stress and myocardial injury. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after transcatheter aortic valve replacement.

Detailed description

Hyperoxemia can produce various complications, such as excessive oxidative stress, hyperoxia-induced vasoconstriction, increased perfusion heterogeneity, and resultant myocardial injury. Previous studies have been observed higher mortality in patient group maintained with supranormal oxygenation after resuscitation from cardiac arrest. However, the effect of hyperoxia vs. normoxia on myocardial injury during transcatheter aortic valve replacement (TAVR) has not been well investigated. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after TAVR.

Conditions

• Troponin

Interventions

Type	Name	Description
OTHER	normal inspired oxygen fraction	receives inspired oxygen fraction of 0.3
OTHER	high inspired oxygen fraction	receives inspired oxygen fraction of 0.8

Timeline

• Start date: 2017-10-18
• Primary completion: 2022-04-06
• Completion: 2022-07-18
• First posted: 2017-09-25
• Last updated: 2022-07-19

Locations

1 site across 1 country: South Korea