NCT03290898

REPLACE: Can Exercise Replace Inhaled Corticosteroid Treatment in Asthma? A RCT

REPLACE: Can Exercise Replace Inhaled Corticosteroid Treatment in Asthma? A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To evaluate if physical exercise intervention leads to an improved asthma control as measured by Asthma Control Questionnaire (ACQ-5) in such a magnitude that inhaled corticosteroid can be reduces in asthmatics.

Detailed description

At least 102 asthmatics will be randomized 2:1 (2 to training group; 1 to control) and undergo 6 months of intervention or usual lifestyle. Subjects must have confirmed asthma diagnosis, on a stable treatment with inhaled corticosteroid, symptomatic and untrained. At enrollment and during the study asthma medicine is adjusted based on asthma symptoms evaluated by ACQ-5. 6 treatment steps are pre-defined, and if well controlled asthma, subjects are down-titrated one step, if uncontrolled, subjects are uptitrated one step.

Conditions

• Asthma

Interventions

Type	Name	Description
BEHAVIORAL	High Intensity Interval Training	Training (HIIT)

Timeline

• Start date: 2017-10-13
• Primary completion: 2020-06-26
• Completion: 2020-12-04
• First posted: 2017-09-25
• Last updated: 2021-03-15

Locations

1 site across 1 country: Denmark