NCT03290365

The Combination Effect of Platelet-rich Plasma and Hyaluronic Acid for Knee Osteoarthritis

The Combination Long-term Effect of Platelet-rich Plasma and Hyaluronic Acid in Patients With Knee Osteoarthritis: a Prospective Randomized Double-blind Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Tri-Service General Hospital · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. Hence, investigator assess a prospective randomized double-blind controlled trial.

Detailed description

Patients with single or bilateral OA knee will be enrolled and randomized into intervention and control group. One dose of PRP is applied into both groups. One week later, one dose of HA is injected in intervention group and one dose of normal saline is injected in control group. Outcome measurements included visual analog scale (VAS)、Lequesne's severity index、Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)、balance test (Biodex) and analysis of synovial fluid at different follow-up frame (1st month, 3rd month, 6th month and 1 year after treatment).

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
DRUG	platelet rich plasma + Hyaluronic acid	Platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for patients with osteoarthritis of knee.
DRUG	platelet rich plasma + normal saline	The normal salin as the placebo intervention was injection control group.

Timeline

• Start date: 2018-01-10
• Primary completion: 2021-07-01
• Completion: 2021-07-01
• First posted: 2017-09-21
• Last updated: 2021-07-13

Locations

1 site across 1 country: Taiwan