NCT03283410

Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Brasilia University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Adaptative clinical trial (Dixon's Up and Down) for determination of ED95% of propofol concentration for hypnosis under general anesthesia for young and elderly adults.

Detailed description

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Method: adaptative clinical trial (Dixon's Up and Down method) for determination of ED95% of propofol concentration (plasmatic, Marsh model) for hypnosis (BIS ranging from 40 to 60) under general anesthesia for young and elderly adults.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Propofol	Propofol plasmatic concentration (Marsh)

Timeline

• Start date: 2017-01-30
• Primary completion: 2017-01-30
• Completion: 2017-01-30
• First posted: 2017-09-14
• Last updated: 2017-09-14