NCT03282032

Preconditioning of One-lung Ventilation

Preconditioning of One-lung Ventilation for Lung Protection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 136 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.

Detailed description

For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia. Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation. Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery

Conditions

• One Lung Ventilation

Interventions

Type	Name	Description
OTHER	One-lung ventilation	The patient undergoing thoracic surgery is intubated with double lumen tube after induction of general anesthesia with propofol and remifentanil. In the intervention group, 5 cycles of one-lung ventilation preconditioning (2-min of one-lung ventilation and 2-min of two-lung ventilation for 1 cycle) is performed before surgical incision. One-lung ventilation is done at dependent lung with FiO2 100% and tidal volume 6 ml kg-1. Two-lung ventilation is done with FiO2 50%, tidal volume 8 ml kg-1.

Timeline

• Start date: 2017-11-22
• Primary completion: 2018-10-09
• Completion: 2018-10-13
• First posted: 2017-09-13
• Last updated: 2018-11-30

Locations

1 site across 1 country: South Korea