NCT03281707

NIRS and DO2i Correlation

Evaluation of NIRS and DO2i Correlation and Their Relationship With Organ Failure During Cardiac Surgery: a Prospective Monocentric Study.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Centro Cardiologico Monzino · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.

Detailed description

Literature evidences show that levels of DO2i under 262-272 mL/min/m2 during cardiopulmonary by-pass (CPB) are associated with an increased incidence of acute kidney injury (AKI). Furthermore, it has been demonstrated that keeping a NIRS of 75-80% compared to the basal value reduces the risk of perioperative morbidity. On the other hand, a NIRS \< 50% of basal value seems to be predictive of an increase in morbidity. All of those studies had been performed during CPB and knowledge lacks in management of DO2i and NIRS before and after CPB.

Conditions

• Multiorgan Failure
• Perfusion; Complications

Interventions

Type	Name	Description
PROCEDURE	NIRS	NIRS devices patch will be applied on patients' head in order to measure the cerebral saturation of each cerebral emisphere
OTHER	DO2i	Oxygen delivery standardized to the body surface area will be calculate in order to optimize tissue perfusion

Timeline

• Start date: 2017-09-30
• Primary completion: 2018-10-30
• Completion: 2018-10-30
• First posted: 2017-09-13
• Last updated: 2017-09-13