Trials / Terminated
TerminatedNCT03281239
Study of the Impact of Welding Fumes on the Arterial System : RISCAS Study
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 51 (actual)
- Sponsor
- University Hospital, Brest · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.
Detailed description
In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Laser doppler, blood tests, and holter ECG | Diagnostic tests : * laser doppler * blood tests * Holter ECG. No drug and no placebo were used in this arm. |
Timeline
- Start date
- 2017-11-28
- Primary completion
- 2019-06-24
- Completion
- 2019-06-24
- First posted
- 2017-09-13
- Last updated
- 2022-05-05
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03281239. Inclusion in this directory is not an endorsement.