NCT03279653

Pancreatic Exocrine Insufficiency After Bariatric Surgery

Effect of Sleeve Gastrectomy on Pancreatic Exocrine Insufficiency.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Umraniye Education and Research Hospital · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.

Detailed description

Mechanism of weight loss differs in bariatric surgery according to type of surgery. With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss. Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.

Conditions

• Obesity, Morbid
• Pancreatic Insufficiency

Interventions

Type	Name	Description
PROCEDURE	SleeveGastrectomy	Preoperative enzyme test before and after sleeve gastrectomy. Sleeve Gastrectomy will be performed. Preoperative (in one month) and Postoperative (after 3 months) pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.

Timeline

• Start date: 2017-09-01
• Primary completion: 2018-09-01
• Completion: 2018-12-01
• First posted: 2017-09-12
• Last updated: 2017-09-13

Locations

1 site across 1 country: Turkey (Türkiye)