NCT03278119

Sleep Aging and Risk for Alzheimer's 2.0

Sleep Aging and Risk for Alzheimer's Resubmission 2.0

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 158 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.

Conditions

• Alzheimer Disease
• Sleep Apnea

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PET Scan and nocturnal polysomnography	Amyloid PET scans will be used to assess amyloid burden in the brain, and nocturnal polysomnography will be used to assess sleep and cardiopulmonary variables

Timeline

• Start date: 2018-05-01
• Primary completion: 2026-12-25
• Completion: 2026-12-25
• First posted: 2017-09-11
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States