NCT03276442

Biorhythms in Metabolic Tissues

Biological Rhythms in Metabolic Tissues: Impact of Diet

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years – 32 Years
• Healthy volunteers: Accepted

Summary

Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long ("circa diem"). These circadian rhythms exist both centrally, in the brain, but also in the periphery, and are specific to many tissues depending on their main biological function or functions. Whereas these circadian rhythms have been thoroughly characterized in other organisms, their role in humans remain poorly understood, partly because of the difficulty in studying these rhythms in peripheral tissues. The investigators therefore aim to characterize these rhythms in primarily skeletal muscle and adipose tissue in healthy young volunteers (using the so-called constant routine paradigm), and how these rhythms interact with one another at various genetic and molecular levels. At the same time, the investigators aim to study how an unhealthy vs. healthy diet can alter these circadian rhythms, and how they interact with circadian rhythms in other tissue compartments such as those expressed by blood cells.

Conditions

• Sleep Deprivation
• Metabolic Disturbance
• Biological Clocks
• Healthy

Interventions

Type	Name	Description
OTHER	Low-fat dietary intervention	Low-fat diet (5-7 days) preceding extended wakefulness under standardized conditions
OTHER	High-fat dietary intervention	High-fat diet (5-7 days) preceding extended wakefulness under standardized conditions

Timeline

• Start date: 2017-08-31
• Primary completion: 2019-11-30
• Completion: 2019-12-31
• First posted: 2017-09-08
• Last updated: 2017-10-12

Locations

1 site across 1 country: Sweden