NCT03275207

Dexmedetomidine for Prevention of Chronic Postoperative Pain

a Randomized Controlled Trial of Dexmedetomidine on Chronic Postoperative Pain After Breast and Thoracic Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Zhongda Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Chronic postoperative pain (CPSP) is common symptom in patients after surgery, seriously affected the quality of life. Accumulating evidences have demonstrated dexmedetomidine can improve chronic pain. However, the prevention of dexmedetomidine on CPSP remain uncertain.

Detailed description

Chronic postoperative pain (CPSP) is defined as pain persisting at least 3 months after surgery. It is most common in patients who undergoing breast or thoracic surgery. Dexmedetomidine, a adrenergic α2 agonists, can alleviate the postoperative pain 24 h after surgery. In our study, patients were randomly assigned to one of the two group to receive 0.5mg/kg/h infusion dexmedetomidine (Group D, n=57) or normal saline (Group C, n=57). The pain scales were evaluated day 1, day 2, day 3, month 3, month 6 after surgery.

Conditions

• Chronic Postoperative Pain

Interventions

Type	Name	Description
DRUG	saline	an equal volume of saline
DRUG	dexmedetomidine	dexmedetomidine, 0.5ug/kg/h by intravenous infusion, intraoperative

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-10-01
• Completion: 2018-10-01
• First posted: 2017-09-07
• Last updated: 2017-12-05

Locations

1 site across 1 country: China