NCT03275181

Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer

Effect of Androgen Deprivation Therapy on Left Ventricular Function in Prostate Cancer Patients and Survivors

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: Kansas State University · Academic / Other
• Sex: Male
• Age: 21 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients. If found successful, this may lead to improved cardiovascular health via treatment and/or lifestyle interventions in prostate cancer populations.

Detailed description

Prostate Cancer is the second most common cancer among American men. Approximately 1 in 7 men will be diagnosed with prostate cancer during his lifetime. In prostate cancer patients alone, hypotestosteronemia, caused by prostate cancer treatment is associated with visceral adiposity, insulin resistance, metabolic syndrome, decreased high-density lipoprotein, increased low-density lipoprotein, increased triglycerides, loss of muscle mass, erectile disfunction, and a loss of microvascular endothelial function. Recently, several population-based studies have reported an association between androgen deprivation therapy and an increased risk of cardiovascular events, that include myocardial infarction and cardiovascular mortality. Given this link and the growing evidence that androgen-deprivation therapy adversely affects traditional risk factors, it is essential to better understand the role this type of treatment has on cardiac structure and function. As such, the manifestation of cardiovascular toxicities with prostate cancer treatment will initially be subclinical (left ventricular function changes in asymptomatic individuals) compared to clinical (including coronary symptoms or heart failure) and may develop subacutely (during treatment) or chronically.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transthoracic Echocardiography	Non-invasive assessment of left ventricle structure and function
DIAGNOSTIC_TEST	Arterial blood pressure	Continuously monitored for 5-30 minutes via finger photoplethysmography
DIAGNOSTIC_TEST	Submaximal Exercise	Incremental exercise test to 85% predicted maximal heart rate on a recumbent cycle ergometer

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-07-31
• Completion: 2018-12-31
• First posted: 2017-09-07
• Last updated: 2025-09-02

Locations

1 site across 1 country: United States