NCT03275116

The Effect of Twice Daily vs. Once Daily Bronchodilation on Hyperinflation in COPD Patients During 24 Hours.

The Effect of Twice Daily Aclidinium Bromide/Formoterol Fumarate 340/12 mcg vs. Once Daily Tiotropium 'Respimat' 5mcg on Static and Dynamic Hyperinflation in Patients With COPD During 24 Hours

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 49 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

To study the effect of twice daily dual bronchodilation versus once daily single bronchodilation in patients with chronic obstructive pulmonary disease on 24-hour static and dynamic hyperinflation.

Detailed description

To study the effect of twice daily dual bronchodilation (Aclidinium Bromide/Formoterol Fumarate 340/12 mcg) versus once daily single bronchodilation (Tiotropium 'respimat' 5 mcg) in patients with COPD on 24-hour static and dynamic hyperinflation, spirometry respiratory symptoms and sleep quality.

Conditions

• Chronic Obstructive Airway Disease

Interventions

Type	Name	Description
DRUG	Tiotropium 'Respimat' 5 mcg	Once daily single bronchodilation
DRUG	Aclidinium Bromide/Formoterol Fumarate 340/12 mcg	Twice daily dual bronchodilation

Timeline

• Start date: 2017-07-07
• Primary completion: 2020-04-01
• Completion: 2020-12-01
• First posted: 2017-09-07
• Last updated: 2020-03-10

Locations

1 site across 1 country: Netherlands