Trials / Completed
CompletedNCT03272646
Prognostic Performance of the Naples Prognostic Score
The Naples Prognostic Score in Gastric Cancer Patients Undergoing Surgery
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 477 (actual)
- Sponsor
- University of Campania Luigi Vanvitelli · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
To investigate the prognostic performance of the Naples Prognostic Score in gastric cancer patients undergoing surgery
Detailed description
The outcome of oncological patients is related not only to the tumor status but also to the host. Particularly the patient's immune and nutritional status have been recently associated with short- and long-term outcome in gastric and other cancers. In addition, there is growing evidence that systemic inflammation plays a crucial role in the carcinogenesis and progression of gastric cancer. The neutrophil to lymphocyte ratio (NLR), and, more recently, the lymphocyte to monocyte ratio (LMR) have been shown to be independently correlated with prognosis in patients with gastric cancer who underwent surgery, and preoperative albumin and cholesterol levels seem to be adequate mirrors of the nutritional status of the host. The investigators have already demonstrated that a new scoring system, which they called Naples prognostic score (NPS), based on a composite score of albumin and cholesterol concentrations, along with NLR and LMR is a simple tool strongly associated with long-term outcome in patients undergoing surgery for colorectal cancer. The aim of this study is to assess the correlation between the NPS and clinicopathological characteristics, postoperative complication rate and long-term outcome in patients undergoing surgery for gastric cancer. Furthermore, the new prognostic scoring system will be compared with previously developed ones and the current TNM staging system to evaluate its performance. All patients who underwent surgery for proven gastric adenocarcinoma at the Division of Surgical Oncology of the Gastrointestinal Tract of the University of Campania (Naples, Italy), from January 2000 to December 2015 will be enrolled in the present study.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | surgery | gastric resection or total gastrectomy |
Timeline
- Start date
- 2000-01-01
- Primary completion
- 2015-12-31
- Completion
- 2017-06-30
- First posted
- 2017-09-05
- Last updated
- 2017-09-05
Source: ClinicalTrials.gov record NCT03272646. Inclusion in this directory is not an endorsement.