NCT03265704

Maternal High Blood Pressure and Newborn's Blood Profile

Maternal Pregnancy Induced Hypertension and Hematological Profile of Newborns

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 6,108 (actual)
• Sponsor: Romanian Society of Anesthesia and Intensive Care · Academic / Other
• Sex: All
• Age: 1 Day – 28 Days
• Healthy volunteers: Not accepted

Summary

Maternal high blood pressure remodels the intrauterine environment of the fetus by altering hormonal and cellular signaling patterns and, as a result increases the risk of fetal and neonatal mortality and morbidity. Newborns of these mothers have an increased risk of intrauterine growth restriction, premature birth and hematological abnormalities, such as thrombocytopenia, polycythemia, and neutropenia. The purpose of the article is to review neonatal thrombocytopenia and neutropenia as a consequence of maternal high blood pressure and to establish the optimal management of these cases.

Detailed description

Pregnancy induced hypertension (PIH) and preeclampsia (preE) are caused by gestation and have an onset after 20 weeks of pregnancy. Although the exact etiology of PIH and preE remains unknown, two interconnected mechanisms have been identified to play an important role in the pathogenesis: dysfunction of the placental trophoblast and endothelial dysfunction within the maternal systemic vasculature. The endothelium has been identified as the target tissue of the disease. Endothelial alterations ultimately manifest as placental hypoxia and hypoplasia. The neonatal thrombocytopenia and neutropenia after pregnancy-induced hypertension is a result of inhibition of fetal bone marrow production of the myeloid lineage due to intrauterine hypoxic environment. This study aims to investigate the hematological profile in term and preterm infants born to mothers with preeclampsia. The current retrospective observational study was conducted at the Clinic of Obstetrics, Gynecology and Neonatology of the Emergency County Hospital, Timisoara over a period of three years, from January 2014 to December 2016. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Neonatology Department.

Conditions

• Maternal-Fetal Exchange

Interventions

Type	Name	Description
OTHER	AGA - Control group	Data processing from Patient Medical Files
OTHER	SGA - Control group	Data processing from Patient Medical Files
OTHER	AGA-PIH Study group	Monitoring PIH-related changes in the newborn
OTHER	SGA-PIH Study group	Monitoring PIH-related changes in the newborn

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-08-25
• Completion: 2017-08-25
• First posted: 2017-08-29
• Last updated: 2017-08-29

Locations

1 site across 1 country: Romania