Trials / Terminated
TerminatedNCT03263390
Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 6 (actual)
- Sponsor
- University of California, San Diego · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to characterize the neurological basis of obesity and response to surgical and medical treatment by inducing adult pluripotent stem cells into neuronal cells from subjects that have demonstrated extreme response to bariatric surgery or pharmacological treatment for obesity.
Detailed description
The investigators will consent subjects who have achieved extreme response to either bariatric surgery or pharmacologic treatment for obesity and harvest fibroblasts from skin biopsies, which will be reprogrammed to induced pluripotent stem cells (iPSC). These iPSC's will then be differentiated into neural progenitor cells, neurons, astrocytes, and microglia to identify genetic and epigenetic pathways altered in disease-specific neural progenitor cells of the brain.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Bariatric Surgery | Sleeve gastrectomy or Roux-en-Y Gastric Bypass |
| DRUG | Anti Obesity Drugs | Response to FDA approved anti obesity medications |
Timeline
- Start date
- 2017-10-05
- Primary completion
- 2020-08-10
- Completion
- 2020-08-10
- First posted
- 2017-08-28
- Last updated
- 2020-12-16
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03263390. Inclusion in this directory is not an endorsement.