NCT03261908

A Pharmacogenomics Study of Simvastatin-Induced Adverse Drug Reaction

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,200 (estimated)
• Sponsor: Cui Yimin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Adverse reactions of simvastatin are mostly slight and transient, however, the incidence of simvastatin-induced hepatic impairment and myopathy are obviously higher in Chinese population than other racial groups. There is still lack of research data in Chinese. In this study, we will investigate whether there are specific genotypes which may predict the incidence of simvastatin-induced hepatic impairment and myopathy in Chinese so as to provide a basis for developing guidelines on precise medication in simvastatin therapy apply to Chinese population.

Conditions

• Simvastatin Adverse Reaction
• Pharmacogenomics
• Accurate Medication

Interventions

Type	Name	Description
GENETIC	detection of genotype	detection of genotype by next generation sequencing

Timeline

• Start date: 2018-08-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2017-08-25
• Last updated: 2018-05-22

Locations

1 site across 1 country: China