NCT03261752

New Genes in the Carcinogenesis of Colorectal Cancer

Investigating the Role of SPG20,STK31 Genes in the Carcinogenesis of Colorectal Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 62 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Colo rectal cancer is one of the greatest ,mutual malignancies worldwide ,accounting for an estimated 1.3 million new cases and \>500,000 mortality ⁄ year . is the fourth leading cause of cancer-associated mortality worldwide with speedily ,cumulative ,occurrence rate in the worldwide

Detailed description

colo rectal cancer represents a global and local problem, as it is one of the commonest types of cancer all over the world. Globally, Colo rectal cancer in women (9.2% of diagnoses) it is the second most common cause of cancer . it is the third most common in men (10.0%). After lung, stomach, and liver cancer it is the fourth most common cause of cancer death. Cancer is a multistep procedure resulting from an ongoing accretion of genetic and epigenetic fluctuations to the genome. Spartin is a protein that in humans is encoded by the SPG20 gene. This protein may be involved in endosomal trafficking, microtubule dynamics, or both functions. Aberrant promoter methylation of genes is a common epigenetic alteration in colo rectal cancer . This has stimulated the prospect to implement a dependable, reasonable and simple approach for Colo rectal detection . The SPG20 gene is situated in chromosome band 13q13.3; the SPG20 gene converts the spartin protein, which is a multi functional protein that has formerly been recognized to be complicated in intra cellular epidermal growth factor receptor trading , The serine-threonine kinase 31 (STK31) gene was initially identified through cDNA subtraction as a testis-specific protein kinase gene expressed in mouse spermatogonia . Recently, STK31 has been described as a novel cancer testis (CT) antigen, highly expressed in Gastrointestinal cancer cells (colo rectal, gastric and esophageal cancer), while restricted to testis and fetal brain in normal tissues . It was found that SPG20 is mutated in Troy er syndrome, an hereditary spastic paraplegia

Conditions

• Colo-rectal Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	blood sample	Total genomic DNA will be extracted DNA extraction kit using a QIAamp DNA Blood Mini kit .Genetic analysis of both SPG20 \&STK31 by RTPCR.

Timeline

• Start date: 2018-10-01
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2017-08-25
• Last updated: 2018-07-26