Trials / Active Not Recruiting
Active Not RecruitingNCT03253952
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.
PROSPECT ADDITION SCI - A PROSPECTive Study of Autonomic Dynamic Dysfunction to Predict infecTIONs After Spinal Cord Injury
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Ohio State University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI). SCI-AI impair outcomes by (1) reducing the intrinsic neurological recovery potential and (2) increasing mortality. Heart Rate Variability (HRV) data will be tracked in both the time and frequency domains to discriminate between the relative contribution of sympathetic and parasympathetic innervation to changes in HRV. The ability to predict infections will enable novel treatments thereby reducing infection-associated mortality and improving neurological and functional outcomes.
Conditions
Timeline
- Start date
- 2017-09-29
- Primary completion
- 2025-06-30
- Completion
- 2027-12-31
- First posted
- 2017-08-18
- Last updated
- 2025-08-11
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03253952. Inclusion in this directory is not an endorsement.